The Harm-Benefit Analysis (HBA) is undertaken, on behalf of the Secretary of State, by the Animals in Science Regulation Unit inspectors, all of whom are veterinary or medically qualified and trained in assessing research proposals. The HBA is the process of considering a research proposal to make a judgement whether the likely harms that the animals will experience are justified by the likely benefits. Under section 18 of the Animals (Scientific Procedures) Act 1986, inspectors advise the Secretary of State who decides whether and on what terms a project licence should be granted.
The number of project licences which were recommended for grant by the Animals in Science Regulation Unit inspectors between 2012 and 2015 are shown in table 1, column (c).
The Secretary of State has not rejected any of the recommendations for granting project licences made by the Animals in Science Regulation Unit inspectors between 2012 and 2015.
The Home Office does not keep records of applications that have been rejected or withdrawn at the concept or drafting stage . The Home Office does not keep records of which applications were withdrawn as a result of advice from the Animals in Science Regulation Unit inspectors.
The Home Office refers project licence applications to both the Animals in Science Committee and external independent assessors for critical review. The number of project licences referred to both is given in Table 1 columns (a) and (b) respectively for the years 2012-15.
(a) Project licence applications referred to the Animals in Science Committee
(b) Project licence applications referred to independent assessors
(c) Project licences granted
 Prior to 2013 the independent advisory body was entitled the ‘Animals Procedures Committee’